Endocrine Abstracts

In humans, adrenarche represents a unique endocrine process manifest by the development of the adrenal zonal reticularis and its production of a group of steroids often called the ‘adrenal androgens’. The physiologic manifestations of adrenarche are reflected by enhanced dehydroepiandrosterone sulfate (DHEA-S) production and the onset of adult body odor, mild acne and axillary and/or pubic hair. Clinically, the early rise in adrenal androgens is termed premature adre...

In humans, adrenarche represents a unique endocrine process manifest by the development of the adrenal zonal reticularis and its production of a group of steroids often called the ‘adrenal androgens’. The physiologic manifestations of adrenarche are reflected by enhanced dehydroepiandrosterone sulfate (DHEA-S) production and the onset of adult body odor, mild acne and axillary and/or pubic hair. Clinically, the early rise in adrenal androgens is termed premature adre...

Many organs are functionally sexually dimorphic, resulting in profound differences in the activity of several physiological systems, including the hypothalamic-pituitary-adrenal (HPA) axis. The rodent HPA axis matures post-weaning, characterized by parallel increments in adrenal weight, adrenal cortical size and corticosterone secretion. Between postnatal days (PND) 30 to 45, these parameters increase to a greater extent in females compared to males. Over this same interval, h...